FDA changed peptide compounding rules several times in 2026. We update this guide when FDA acts.
What is NAD+?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme every cell uses to turn food into energy. Levels decline with age. Injectable NAD+ is used in longevity and recovery protocols; injecting too fast can cause flushing, nausea or chest tightness, so dosing is started slowly.
Status: Available now · compounded to order
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What is Sermorelin?
Sermorelin is a peptide copy of the first 29 amino acids of growth hormone-releasing hormone (GHRH). It prompts the pituitary to release the body's own growth hormone rather than supplying it directly, and is usually injected under the skin at bedtime.
Status: Available now · compounded to order
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What is Tesamorelin?
Tesamorelin is a synthetic GHRH analog and the active ingredient in Egrifta, which FDA approved to reduce excess abdominal fat in adults with HIV-associated lipodystrophy. It raises the body's own growth hormone and IGF-1. It is injected daily and requires a prescription.
Status: FDA-approved ingredient · prescription required
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What is BPC-157?
BPC-157 (Body Protection Compound-157) is a 15-amino-acid peptide derived from a protein in human gastric juice. It has been studied mostly in animals, for gut-lining protection and tendon, ligament and muscle repair; human clinical data are limited.
Status: Removed from FDA's Category 2 list in April 2026. FDA's advisory committee voted 8–6 in July 2026 to add it to the 503A bulks list. Not yet compoundable: FDA must finalize the change through rulemaking.
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What is TB-500?
TB-500 is a synthetic fragment of thymosin beta-4, a protein involved in cell migration, blood-vessel formation and tissue repair. It is studied for soft-tissue recovery and is often discussed with BPC-157.
Status: Removed from FDA's Category 2 list in April 2026. FDA's advisory committee voted 8–6 in July 2026 to add it to the 503A bulks list. Not yet compoundable: FDA must finalize the change through rulemaking.
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What is KPV?
KPV is a three-amino-acid peptide (lysine–proline–valine) from the tail of alpha-melanocyte-stimulating hormone (alpha-MSH). It is studied for anti-inflammatory effects in the gut and skin.
Status: Removed from FDA's Category 2 list in April 2026. FDA's advisory committee voted 8–6 in July 2026 to add it to the 503A bulks list. Not yet compoundable: FDA must finalize the change through rulemaking.
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What is MOTS-c?
MOTS-c is a 16-amino-acid peptide encoded by mitochondrial DNA. It acts as a metabolic signal and is studied for insulin sensitivity, glucose metabolism and exercise capacity.
Status: Removed from FDA's Category 2 list in April 2026. FDA's advisory committee voted 7–5 in July 2026 to add it to the 503A bulks list. Not yet compoundable: FDA must finalize the change through rulemaking.
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What is GHK-Cu?
GHK-Cu (copper tripeptide-1) is a naturally occurring peptide that binds copper; levels decline with age. It is best known for skin use: collagen and elastin support, firmness and wound healing.
Status: Topical GHK-Cu: on FDA's Category 1 list, so it can be compounded. Injectable GHK-Cu: removed from Category 2 in April 2026, with an advisory-committee review expected by February 2027.
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What is Epitalon?
Epitalon (also spelled epithalon) is a four-amino-acid peptide modeled on a pineal-gland extract. It is studied for sleep, circadian rhythm and aging; human data are limited.
Status: Removed from FDA's Category 2 list in April 2026. FDA's advisory committee voted 7–4 in July 2026 to add it to the 503A bulks list. Not yet compoundable: FDA must finalize the change through rulemaking.
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What is Semax?
Semax is a synthetic peptide derived from a fragment of ACTH (adrenocorticotropic hormone). It is used clinically in Russia and studied for attention, memory and stroke recovery.
Status: Removed from FDA's Category 2 list in April 2026. FDA's advisory committee voted 8–5 in July 2026 to add it to the 503A bulks list. Not yet compoundable: FDA must finalize the change through rulemaking.
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What is Retatrutide?
Retatrutide (LY3437943) is an investigational once-weekly injection from Eli Lilly that activates three receptors: GIP, GLP-1 and glucagon. Lilly plans to submit it to FDA in the first quarter of 2027. It is not FDA-approved and cannot legally be compounded; "research-use" vials sold online are unapproved and unregulated.
Status: Investigational · not FDA-approved
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Educational information, not medical advice. Peptide therapy should be prescribed and monitored by a licensed provider.